516 East Second Street
Take the red line to the Broadway stop. Walk up West Broadway to H Street. Go left on H Street, down two blocks to the intersection of H Street and East 2nd Street. The Distillery will be on your left. This walk takes ten to fifteen minutes. You can also take the #9 bus directly from the bus stop at the Broadway T station, and get off at H Street and then follow the directions above.
You can also take the #9 from Copley Square, next to the Boston Public Library, or from many other locations, See the MBTA website for connections and schedules.